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KMID : 1094720080130020204
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Biotechnology and Bioprocess Engineering
2008 Volume.13 No. 2 p.204 ~ p.209
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Mechanical behavior of a new biphasic calcium phosphate bone graft
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Rabiee S. M.
Mortazavi S. M. J.
Moztarzadeh F.
Sharifi D.
Sharifi Sh.
Solati-Hashjin M.
Salimi-Kenari H.
Bizari D.
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Abstract
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The aim of this study was to create a new porous calcium phosphate implant for use as a synthetic bone graft substitute. Porous bioceramic was fabricated using a foam-casting method. By using polyurethane foam and a slurry containing hydroxyapatite-dicalcium phosphate powder, water, and additives, a highly porous structure (66 ± 5%) was created. The porous specimens possess an elastic modulus of 330 ± 32 MPa and a compressive strength of 10.3 ± 1.7 MPa. The X-ray diffraction patterns show hydroxyapatite and beta-pyrophosphate phases after sintering. A rabbit model was developed to evaluate the compressive strength and elastic modulus of cancellous bone defects treated with these porous synthetic implants. The compressive mechanical properties became weaker until the second month post implantation. After the second month, these properties increased slightly and remained higher than control values. New bone formed on the outside surface and on the macropore walls of the specimens, as osteoids and osteoclasts were evident two months postoperatively. Considering these properties, these synthetic porous calcium phosphate implants could be applicable as cancellous bone substitutes.
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KEYWORD
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bone graft, porous bioceramic, biphasic calcium phosphate, in vivo, mechanical behavior
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